| Gene Information | |
|---|---|
| Gene Name | SYVN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 617 |
| Protein Names | E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000162298 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86TM6 |
| Gene Card | SYVN1 |
| Uniprot ID | Q86TM6 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.593360357) |
| Ortholog in Animals | Alpaca_ SYVN1 ( ortholog_one2one ) Dog_ SYVN1 ( ortholog_one2one ) GuineaPig_ SYVN1 ( ortholog_one2one ) Macaque_ SYVN1 ( ortholog_one2one ) Mouse_ Syvn1 ( ortholog_one2one ) Pig_ SYVN1 ( ortholog_one2one ) Rat_ Syvn1 ( ortholog_one2one ) Rabbit_ SYVN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF139, AMFR, RNF145, DZIP3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.060163(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6A3Z (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:26471130}; Multi-pass membrane protein {ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16186510}. |
| Mouse PG classification | NA |
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