| Gene Information | |
|---|---|
| Gene Name | MADCAM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 382 |
| Protein Names | Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1) |
| Target Name | mucosal addressin cell adhesion molecule 1 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000099866 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q13477 |
| Gene Card | MADCAM1 |
| Uniprot ID | Q13477 |
| Pfam | PF09085 |
| In ASD | no |
| Allosteric Prediction | no (-0.715569981) |
| Ortholog in Animals | Alpaca_ MADCAM1 ( ortholog_one2one ) Dog_ MADCAM1 ( ortholog_one2one ) Macaque_ MADCAM1 ( ortholog_one2one ) Mouse_ Madcam1 ( ortholog_one2one ) Pig_ MADCAM1 ( ortholog_one2one ) Rat_ Madcam1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, spleen, gall.bladder |
| Tissue Specificity | Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. {ECO:0000269|PubMed:8609404, ECO:0000269|PubMed:8989586}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BQS (X-ray 2.20A ) 1GSM (X-ray 1.90A ) 4HBQ (X-ray 1.40A ) 4HC1 (X-ray 2.87A ) 4HCR (X-ray 2.30A ) 4HD9 (X-ray 1.70A ) |
| DBSNP | rs3745925 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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