| Gene Information | |
|---|---|
| Gene Name | SYT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 419 |
| Protein Names | Synaptotagmin-2 (Synaptotagmin II) (SytII) |
| Target Name | synaptotagmin-2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000143858 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N9I0 |
| Gene Card | SYT2 |
| Uniprot ID | Q8N9I0 |
| Pfam | PF00168 |
| In ASD | no |
| Allosteric Prediction | yes (0.360802316) |
| Ortholog in Animals | Alpaca_ SYT2 ( ortholog_one2one ) Dog_ SYT2 ( ortholog_one2one ) GuineaPig_ SYT2 ( ortholog_one2one ) Macaque_ SYT2 ( ortholog_one2one ) Mouse_ Syt2 ( ortholog_one2one ) Pig_ SYT2 ( ortholog_one2one ) Rat_ Syt2 ( ortholog_one2one ) Rabbit_ SYT2 ( ortholog_one2one ) |
| Ohnologs | SYT1, SYT5 |
| Paralogs | SYTL3, SYT13, TC2N, SYT1, SYT7, SYTL4, SYTL5, DOC2B, DOC2A, SYT14, C2CD4C, SYTL1, RPH3A, SYT8, SYT4, SYT11, SYT12, C2CD4A, C2CD4B, RPH3AL, SYT15, SYT15B, SYT9, SYT16, SYT6, C2CD4D, SYT3, SYTL2, SYT10, SYT5, SYT17 |
| Tissue | brain, cerebellum, diencephalon, locus.ceruleus, middle.frontal.gyrus, occipital.cortex, occipital.lobe, parietal.lobe, pineal.gland, cerebellar.hemisphere |
| Tissue Specificity | Expressed at the neuromuscular junction (PubMed:33659639). Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:33659639}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.087912(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6G5G (X-ray 2.00A ) |
| DBSNP | rs587777781 rs587777782 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | LPG |
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