| Gene Information | |
|---|---|
| Gene Name | SYT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 422 |
| Protein Names | Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000067715 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21579 |
| Gene Card | SYT1 |
| Uniprot ID | P21579 |
| Pfam | PF00168 |
| In ASD | no |
| Allosteric Prediction | yes (0.840701915) |
| Ortholog in Animals | Alpaca_ SYT1 ( ortholog_one2one ) Dog_ SYT1 ( ortholog_one2one ) GuineaPig_ SYT1 ( ortholog_one2one ) Macaque_ SYT1 ( ortholog_one2one ) Mouse_ Syt1 ( ortholog_one2one ) Pig_ SYT1 ( ortholog_one2one ) Rat_ Syt1 ( ortholog_one2one ) Rabbit_ SYT1 ( ortholog_one2one ) |
| Ohnologs | SYT5, SYT2 |
| Paralogs | SYT2, SYTL3, SYT13, TC2N, SYT7, SYTL4, SYTL5, DOC2B, DOC2A, SYT14, C2CD4C, SYTL1, RPH3A, SYT8, SYT4, SYT11, SYT12, C2CD4A, C2CD4B, RPH3AL, SYT15, SYT15B, SYT9, SYT16, SYT6, C2CD4D, SYT3, SYTL2, SYT10, SYT5, SYT17 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.091925(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2K45 (NMR - ) 2K4A (NMR - ) 2K8M (NMR - ) 2KI6 (NMR - ) 2LHA (NMR - ) 2N1T (NMR - ) 2R83 (X-ray 2.70A ) 3F00 (X-ray 1.36A ) 3F01 (X-ray 1.70A ) 3F04 (X-ray 1.35A ) 3F05 (X-ray 1.40A ) 4ISQ (X-ray 2.65A ) 4V11 (X-ray 1.95A ) 6G5F (X-ray 2.50A ) 6G5K (X-ray 2.00A ) 6QNS (X-ray 2.40A ) 6TZ3 (X-ray 1.17A ) 6U41 (X-ray 1.70A ) 6U4U (X-ray 1.30A ) 6U4W (X-ray 1.40A ) 6ZVN (X-ray 2.50A ) |
| DBSNP | rs1135402761 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}. |
| Mouse PG classification | NA |
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