| Gene Information | |
|---|---|
| Gene Name | SYP |
| Organism | Homo sapiens (Human) |
| Gene Length | 313 |
| Protein Names | Synaptophysin (Major synaptic vesicle protein p38) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000102003 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08247 |
| Gene Card | SYP |
| Uniprot ID | P08247 |
| Pfam | PF01284 |
| In ASD | no |
| Allosteric Prediction | yes (0.279597818) |
| Ortholog in Animals | Alpaca_ SYP ( ortholog_one2one ) Dog_ SYP ( ortholog_one2one ) GuineaPig_ SYP ( ortholog_one2one ) Macaque_ SYP ( ortholog_one2one ) Mouse_ Syp ( ortholog_one2one ) Pig_ SYP ( ortholog_one2one ) Rat_ Syp ( ortholog_one2one ) |
| Ohnologs | SYPL1, SYPL2, SYNPR |
| Paralogs | SYPL2, SYPL1, SYNPR |
| Tissue | brain, cerebral.cortex, adrenal.gland |
| Tissue Specificity | Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3 (PubMed:8838578). Expressed in the putamen (at protein level) (PubMed:17296554). {ECO:0000269|PubMed:17296554, ECO:0000269|PubMed:8838578}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs200470034 rs137852561 rs782086106 rs139475570 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18662323}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:18662323}. |
| Mouse PG classification | NA |
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