| Gene Information | |
|---|---|
| Gene Name | SYNPO2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1093 |
| Protein Names | Synaptopodin-2 (Genethonin-2) (Myopodin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000172403 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UMS6 |
| Gene Card | SYNPO2 |
| Uniprot ID | Q9UMS6 |
| Pfam | PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-0.344976647) |
| Ortholog in Animals | Alpaca_ SYNPO2 ( ortholog_one2one ) Dog_ SYNPO2 ( ortholog_one2one ) GuineaPig_ SYNPO2 ( ortholog_one2one ) Macaque_ SYNPO2 ( ortholog_one2one ) Mouse_ Synpo2 ( ortholog_one2one ) Pig_ SYNPO2 ( ortholog_one2one ) Rat_ Synpo2 ( ortholog_one2one ) Rabbit_ SYNPO2 ( ortholog_one2one ) |
| Ohnologs | SYNPO2L |
| Paralogs | SYNPO, SYNPO2L |
| Tissue | NA |
| Tissue Specificity | Expressed in heart muscle. Isoform 5 is specifically expressed in skeletal muscle. {ECO:0000269|PubMed:11297942, ECO:0000269|PubMed:20554076}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs12645298 rs17263971 rs17050152 rs7698598 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q91YE8}. Cytoplasm {ECO:0000250|UniProtKB:Q91YE8}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:20554076}. Cell junction, focal adhesion {ECO:0000269|PubMed:20554076}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern, partly overlapping with filamentous actin (PubMed:18371299). {ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:18371299}.; [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with contiguous staining. {ECO:0000269|PubMed:24005909}.; [Isoform 2]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with punctuate staining. {ECO:0000269|PubMed:24005909}.; [Isoform 3]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced irregular actin bundles with contiguous and punctuated staining. {ECO:0000269|PubMed:24005909}.; [Isoform 4]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with punctuate staining. {ECO:0000269|PubMed:24005909}.; [Isoform 5]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24005909}. Note=Localizes to induced actin bundles with contiguous staining. {ECO:0000269|PubMed:24005909}. |
| Mouse PG classification | NA |
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