| Gene Information | |
|---|---|
| Gene Name | SYNM |
| Organism | Homo sapiens (Human) |
| Gene Length | 1565 |
| Protein Names | Synemin (Desmuslin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000182253 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O15061 |
| Gene Card | SYNM |
| Uniprot ID | O15061 |
| Pfam | PF00038 |
| In ASD | no |
| Allosteric Prediction | no (-0.914836676) |
| Ortholog in Animals | Alpaca_ SYNM ( ortholog_one2one ) GuineaPig_ SYNM ( ortholog_one2one ) Macaque_ SYNM ( ortholog_one2one ) Mouse_ Synm ( ortholog_one2one ) Rat_ Synm ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:11737198}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6EWO (X-ray 2.30A ) |
| DBSNP | rs2305445 rs5030691 rs3743242 rs3134595 rs3743244 rs5030692 rs3743247 rs5030694 rs5030695 rs5030697 rs5030698 rs5030699 rs9920074 rs7167599 rs2292288 rs2292287 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere. |
| Mouse PG classification | NA |
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