| Gene Information | |
|---|---|
| Gene Name | SYNJ1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1573 |
| Protein Names | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000159082 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43426 |
| Gene Card | SYNJ1 |
| Uniprot ID | O43426 |
| Pfam | PF08952; PF03372; PF02383 |
| In ASD | no |
| Allosteric Prediction | yes (0.145977732) |
| Ortholog in Animals | Alpaca_ SYNJ1 ( ortholog_one2one ) Alpaca_ SYNJ1 ( ortholog_one2many ) Dog_ SYNJ1 ( ortholog_one2one ) GuineaPig_ SYNJ1 ( ortholog_one2one ) Macaque_ SYNJ1 ( ortholog_one2one ) Mouse_ Synj1 ( ortholog_one2one ) Pig_ SYNJ1 ( ortholog_one2one ) Rat_ Synj1 ( ortholog_one2one ) Rabbit_ SYNJ1 ( ortholog_one2one ) |
| Ohnologs | SYNJ2 |
| Paralogs | SH2D1B, SH2D1A, FIG4, INPP5E, SYNJ2, SACM1L, OCRL, INPP5D, INPPL1, INPP5F, INPP5J, INPP5B, INPP5K |
| Tissue | NA |
| Tissue Specificity | Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1W80 (X-ray 1.90A ) 2DNR (NMR - ) 2VJ0 (X-ray 1.60A ) 7A0V (X-ray 2.30A ) |
| DBSNP | rs398122403 rs2254562 rs1060499619 rs1057524877 rs115683257 rs9980589 rs769099271 rs2230767 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}. |
| Mouse PG classification | HPG |
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