| Gene Information | |
|---|---|
| Gene Name | UQCRC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) |
| Target Name | cytochrome b-c1 complex subunit 1, mitochondrial |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000010256 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P31930 |
| Gene Card | UQCRC1 |
| Uniprot ID | P31930 |
| Pfam | PF00675; PF05193 |
| In ASD | no |
| Allosteric Prediction | yes (0.163937286) |
| Ortholog in Animals | Alpaca_ UQCRC1 ( ortholog_one2one ) Dog_ UQCRC1 ( ortholog_one2one ) GuineaPig_ UQCRC1 ( ortholog_one2one ) Macaque_ UQCRC1 ( ortholog_one2one ) Mouse_ Uqcrc1 ( ortholog_one2one ) Pig_ UQCRC1 ( ortholog_one2one ) Rat_ Uqcrc1 ( ortholog_one2one ) Rabbit_ UQCRC1 ( ortholog_one2one ) |
| Ohnologs | PMPCB |
| Paralogs | PMPCA, PITRM1, NRDC, UQCRC2, PMPCB, IDE |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, including substantia nigra, striatum, cortex and cerebellum, and in spinal cord, heart, kidney, liver and muscle. {ECO:0000269|PubMed:33141179}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.642327(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5XTE (EM 3.40A ) 5XTH (EM 3.90A ) 5XTI (EM 17.40A ) |
| DBSNP | rs17080284 rs144710790 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07256}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07256}; Matrix side {ECO:0000250|UniProtKB:P07256}. |
| Mouse PG classification | NA |
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