| Gene Information | |
|---|---|
| Gene Name | SYK |
| Organism | Homo sapiens (Human) |
| Gene Length | 635 |
| Protein Names | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) |
| Target Name | tyrosine-protein kinase syk |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000165025 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P43405 |
| Gene Card | SYK |
| Uniprot ID | P43405 |
| Pfam | PF07714; PF00017 |
| In ASD | yes |
| Allosteric Prediction | yes (1.430149402) |
| Ortholog in Animals | Alpaca_ SYK ( ortholog_one2one ) Dog_ SYK ( ortholog_one2one ) GuineaPig_ SYK ( ortholog_one2one ) Macaque_ SYK ( ortholog_one2one ) Mouse_ Syk ( ortholog_one2one ) Pig_ SYK ( ortholog_one2one ) Rat_ Syk ( ortholog_one2one ) Rabbit_ SYK ( ortholog_one2one ) |
| Ohnologs | ZAP70 |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in hematopoietic cells (at protein level) (PubMed:8163536). Expressed in neutrophils (at protein level) (PubMed:15123770). Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells (PubMed:8163536). {ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:8163536}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.013150(Mouse);0.266375(Rat);0.034043(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A81 (X-ray 3.00A ) 1CSY (NMR - ) 1CSZ (NMR - ) 1XBA (X-ray 2.00A ) 1XBB (X-ray 1.57A ) 1XBC (X-ray 2.00A ) 3BUW (X-ray 1.45A ) 3EMG (X-ray 2.60A ) 3FQE (X-ray 2.50A ) 3FQH (X-ray 2.26A ) 3FQS (X-ray 2.10A ) 3SRV (X-ray 1.95A ) 3TUB (X-ray 2.23A ) 3TUC (X-ray 2.10A ) 3TUD (X-ray 2.33A ) 3VF8 (X-ray 2.08A ) 3VF9 (X-ray 2.30A ) 4DFL (X-ray 1.98A ) 4DFN (X-ray 2.48A ) 4F4P (X-ray 2.37A ) 4FL1 (X-ray 1.79A ) 4FL2 (X-ray 2.19A ) 4FL3 (X-ray 1.90A ) 4FYN (X-ray 2.32A ) 4FYO (X-ray 1.40A ) 4FZ6 (X-ray 1.85A ) 4FZ7 (X-ray 1.75A ) 4GFG (X-ray 2.35A ) 4I0R (X-ray 2.10A ) 4I0S (X-ray 1.98A ) 4I0T (X-ray 1.70A ) 4PUZ (X-ray 2.08A ) 4PV0 (X-ray 2.00A ) 4PX6 (X-ray 1.60A ) 4RSS (X-ray 1.83A ) 4RX7 (X-ray 1.80A ) 4RX8 (X-ray 1.59A ) 4RX9 (X-ray 1.75A ) 4WNM (X-ray 2.50A ) 4XG2 (X-ray 2.21A ) 4XG3 (X-ray 2.30A ) 4XG4 (X-ray 2.30A ) 4XG6 (X-ray 2.40A ) 4XG7 (X-ray 1.76A ) 4XG8 (X-ray 2.40A ) 4XG9 (X-ray 2.91A ) 4YJO (X-ray 1.60A ) 4YJP (X-ray 1.83A ) 4YJQ (X-ray 1.34A ) 4YJR (X-ray 1.32A ) 4YJS (X-ray 2.22A ) 4YJT (X-ray 1.52A ) 4YJU (X-ray 1.67A ) 4YJV (X-ray 1.65A ) 5C26 (X-ray 1.95A ) 5C27 (X-ray 2.15A ) 5CXH (X-ray 1.90A ) 5CXZ (X-ray 1.70A ) 5CY3 (X-ray 1.76A ) 5GHV (X-ray 2.80A ) 5LMA (X-ray 1.43A ) 5LMB (X-ray 1.95A ) 5T68 (X-ray 2.93A ) 5TIU (X-ray 1.49A ) 5TR6 (X-ray 1.93A ) 5TT7 (X-ray 1.77A ) 5Y5T (X-ray 1.80A ) 5Y5U (X-ray 2.14A ) 6HM6 (X-ray 2.10A ) 6HM7 (X-ray 1.64A ) 6SSB (X-ray 2.08A ) 6VOV (X-ray 1.95A ) 6ZC0 (X-ray 1.97A ) 6ZCP (X-ray 2.20A ) 6ZCQ (X-ray 2.32A ) 6ZCR (X-ray 1.73A ) 6ZCS (X-ray 1.47A ) 6ZCU (X-ray 1.73A ) 6ZCX (X-ray 1.66A ) 6ZCY (X-ray 1.81A ) 7Q5T (X-ray 2.20A ) 7Q5U (X-ray 2.40A ) 7Q5W (X-ray 2.20A ) 7Q63 (X-ray 1.90A ) 7SA7 (X-ray 3.20A ) |
| DBSNP | rs16906862 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}. Cytoplasm, cytosol {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |