| Gene Information | |
|---|---|
| Gene Name | MBNL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Muscleblind-like protein 2 (Muscleblind-like protein 1) (Muscleblind-like protein-like) (Muscleblind-like protein-like 39) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000139793 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5VZF2 |
| Gene Card | MBNL2 |
| Uniprot ID | Q5VZF2 |
| Pfam | PF00642 |
| In ASD | no |
| Allosteric Prediction | no (-0.987826125) |
| Ortholog in Animals | Alpaca_ MBNL2 ( ortholog_one2one ) Dog_ MBNL2 ( ortholog_one2one ) GuineaPig_ MBNL2 ( ortholog_one2one ) Macaque_ MBNL2 ( ortholog_one2one ) Mouse_ Mbnl2 ( ortholog_one2one ) Pig_ MBNL2 ( ortholog_one2one ) Rat_ Mbnl2 ( ortholog_one2one ) Rabbit_ MBNL2 ( ortholog_one2one ) |
| Ohnologs | MBNL3, MBNL1 |
| Paralogs | MBNL3, MBNL1, ZC3H10 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11929853}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2E5S (NMR - ) 2RPP (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11929853}. Cytoplasm {ECO:0000269|PubMed:16273094}. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques (PubMed:16273094). Location in the cytoplasm is microtubule-dependent (PubMed:16273094). In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts (PubMed:11929853). |
| Mouse PG classification | NA |
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