| Gene Information | |
|---|---|
| Gene Name | OLR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 273 |
| Protein Names | Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form] |
| Target Name | lectin-like oxidized ldl receptor |
| Target Type | Discontinued target |
| Gene Age | 382 ( ENSG00000173391 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P78380 |
| Gene Card | OLR1 |
| Uniprot ID | P78380 |
| Pfam | PF00059; PF08391 |
| In ASD | no |
| Allosteric Prediction | yes (0.424562866) |
| Ortholog in Animals | Alpaca_ OLR1 ( ortholog_one2one ) Dog_ OLR1 ( ortholog_one2one ) GuineaPig_ OLR1 ( ortholog_one2one ) Macaque_ OLR1 ( ortholog_one2one ) Mouse_ Olr1 ( ortholog_one2one ) Pig_ OLR1 ( ortholog_one2one ) Rat_ Olr1 ( ortholog_one2one ) Rabbit_ OLR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD69, CLEC12A, KLRC3, KLRC2, CLEC12B, KLRG2, CLEC2A, KLRF1, CLEC1A, KLRF2, KLRD1, CLEC2B, KLRC1, CLEC2L, KLRG1, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC5A, CLEC2D, CLEC7A, KLRB1 |
| Tissue | lung, placenta, substantia.nigra |
| Tissue Specificity | Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. {ECO:0000269|PubMed:12354387, ECO:0000269|PubMed:9052782, ECO:0000269|PubMed:9828121}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1YPO (X-ray 3.00A ) 1YPQ (X-ray 1.40A ) 1YPU (X-ray 2.05A ) 1YXJ (X-ray 1.78A ) 1YXK (X-ray 2.40A ) 3VLG (X-ray 2.30A ) 6TL7 (X-ray 1.11A ) 6TL9 (X-ray 2.73A ) 6TLA (X-ray 2.16A ) 7R8U (X-ray 1.90A ) |
| DBSNP | rs11053646 |
| Subcellular location [CC] | Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation. |
| Mouse PG classification | NA |
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