| Gene Information | |
|---|---|
| Gene Name | SVIL |
| Organism | Homo sapiens (Human) |
| Gene Length | 2214 |
| Protein Names | Supervillin (Archvillin) (p205/p250) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000197321 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95425 |
| Gene Card | SVIL |
| Uniprot ID | O95425 |
| Pfam | PF00626; PF02209 |
| In ASD | no |
| Allosteric Prediction | no (-0.208165393) |
| Ortholog in Animals | Alpaca_ SVIL ( ortholog_one2one ) Dog_ SVIL ( ortholog_one2one ) GuineaPig_ SVIL ( ortholog_one2one ) Macaque_ SVIL ( ortholog_one2one ) Mouse_ Svil ( ortholog_one2one ) Pig_ SVIL ( ortholog_one2one ) Rat_ Svil ( ortholog_one2one ) Rabbit_ SVIL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIL1, VILL, SCIN, CAPG, AVIL, FLII, GSN |
| Tissue | NA |
| Tissue Specificity | Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. {ECO:0000269|PubMed:9867483}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.017391(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K6M (NMR - ) 2K6N (NMR - ) |
| DBSNP | rs10160013 rs1247696 rs7070135 rs2368406 rs11007612 rs7921306 rs17694739 |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody {ECO:0000250|UniProtKB:O46385}. Cleavage furrow {ECO:0000250|UniProtKB:O46385}. Note=Tightly associated with both actin filaments and plasma membranes. |
| Mouse PG classification | NA |
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