| Gene Information | |
|---|---|
| Gene Name | GFRA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3) |
| Target Name | gdnf receptor alpha-3 |
| Target Type | Clinical trial target |
| Gene Age | 332 ( ENSG00000146013 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O60609 |
| Gene Card | GFRA3 |
| Uniprot ID | O60609 |
| Pfam | PF02351 |
| In ASD | no |
| Allosteric Prediction | no (-0.766200376) |
| Ortholog in Animals | Alpaca_ GFRA3 ( ortholog_one2one ) Dog_ CDC23 ( ortholog_one2one ) GuineaPig_ GFRA3 ( ortholog_one2one ) Macaque_ GFRA3 ( ortholog_one2one ) Mouse_ Gfra3 ( ortholog_one2one ) Pig_ GFRA3 ( ortholog_one2one ) Rat_ Gfra3 ( ortholog_one2one ) Rabbit_ GFRA3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GFRA1, GFRA4, GFRA2, GFRAL |
| Tissue | tibial.nerve |
| Tissue Specificity | Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. {ECO:0000269|PubMed:9576965}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2GH0 (X-ray 1.92A ) 6Q2S (EM 3.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Lipid-anchor, GPI-anchor. |
| Mouse PG classification | NA |
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