Gene Information | |
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Gene Name | SV2A |
Organism | Homo sapiens (Human) |
Gene Length | 742 |
Protein Names | Synaptic vesicle glycoprotein 2A |
Target Name | synaptic vesicle glycoprotein 2a |
Target Type | Successful target |
Gene Age | 987 ( ENSG00000159164 ) |
Evolutionary Stage | Euk+Bac |
AlphaFoldDB | Q7L0J3 |
Gene Card | SV2A |
Uniprot ID | Q7L0J3 |
Pfam | PF07690; PF00083 |
In ASD | yes |
Allosteric Prediction | yes (0.999850259) |
Ortholog in Animals | Alpaca_ SV2A ( ortholog_one2one ) Dog_ SV2A ( ortholog_one2one ) GuineaPig_ SV2A ( ortholog_one2one ) Macaque_ SV2A ( ortholog_one2one ) Mouse_ Sv2a ( ortholog_one2one ) Pig_ SV2A ( ortholog_one2one ) Rat_ Sv2a ( ortholog_one2one ) Rabbit_ SV2A ( ortholog_one2one ) |
Ohnologs | SV2C, SV2B |
Paralogs | SV2B, SV2C |
Tissue | brain, cerebral.cortex, adrenal.gland |
Tissue Specificity | NA |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 4V11 (X-ray 1.95A ) |
DBSNP | NA |
Subcellular location [CC] | Presynapse {ECO:0000250|UniProtKB:Q9JIS5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q02563}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02563}. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q02563, ECO:0000250|UniProtKB:Q9JIS5}. |
Mouse PG classification | NA |
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