| Gene Information | |
|---|---|
| Gene Name | CD109 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1445 |
| Protein Names | CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000156535 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6YHK3 |
| Gene Card | CD109 |
| Uniprot ID | Q6YHK3 |
| Pfam | PF00207; PF07703; PF07677; PF01835; PF17791; PF07678 |
| In ASD | no |
| Allosteric Prediction | no (-0.679256318) |
| Ortholog in Animals | Alpaca_ CD109 ( ortholog_one2one ) Dog_ CD109 ( ortholog_one2one ) GuineaPig_ CD109 ( ortholog_one2one ) Macaque_ CD109 ( ortholog_one2one ) Mouse_ Cd109 ( ortholog_one2one ) Pig_ CD109 ( ortholog_one2one ) Rat_ Cd109 ( ortholog_one2one ) Rabbit_ CD109 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CPAMD8, A2M, C3, A2ML1, PZP, C5, C4B, C4A |
| Tissue | NA |
| Tissue Specificity | Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:14980714, ECO:0000269|PubMed:16754747}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs9446983 rs7741152 rs7742662 rs10455097 rs2351528 rs5023688 rs1454572681 rs35630075 rs2917862 rs13207595 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:16754747}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:16754747}. |
| Mouse PG classification | NA |
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