| Gene Information | |
|---|---|
| Gene Name | SUN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 717 |
| Protein Names | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000100242 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UH99 |
| Gene Card | SUN2 |
| Uniprot ID | Q9UH99 |
| Pfam | PF18580; PF07738 |
| In ASD | no |
| Allosteric Prediction | no (-0.202498845) |
| Ortholog in Animals | Alpaca_ SUN2 ( ortholog_one2one ) Dog_ SUN2 ( ortholog_one2one ) GuineaPig_ SUN2 ( ortholog_one2one ) Macaque_ SUN2 ( ortholog_one2one ) Mouse_ Sun2 ( ortholog_one2one ) Pig_ SUN2 ( ortholog_one2one ) Rat_ Sun2 ( ortholog_one2one ) Rabbit_ SUN2 ( ortholog_one2one ) |
| Ohnologs | SUN1 |
| Paralogs | SUN3, SPAG4, SUN5, SUN1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. {ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:12393179}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3UNP (X-ray 2.39A ) 4DXR (X-ray 2.32A ) 4DXS (X-ray 2.71A ) 4DXT (X-ray 2.22A ) 4FI9 (X-ray 3.05A ) 6WMD (X-ray 1.50A ) 6WME (X-ray 1.53A ) 6WMF (X-ray 2.60A ) 6WMG (X-ray 1.90A ) |
| DBSNP | rs2072799 rs35496634 rs138708 rs2072797 |
| Subcellular location [CC] | Nucleus inner membrane {ECO:0000269|PubMed:15082709}; Single-pass type II membrane protein {ECO:0000269|PubMed:15082709}. Nucleus envelope {ECO:0000269|PubMed:15082709, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:17724119}. Endosome membrane {ECO:0000269|PubMed:10818110}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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