| Gene Information | |
|---|---|
| Gene Name | SUMF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 374 |
| Protein Names | Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000144455 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8NBK3 |
| Gene Card | SUMF1 |
| Uniprot ID | Q8NBK3 |
| Pfam | PF03781 |
| In ASD | no |
| Allosteric Prediction | no (-0.830956752) |
| Ortholog in Animals | Alpaca_ SUMF1 ( ortholog_one2one ) Dog_ SUMF1 ( ortholog_one2one ) GuineaPig_ SUMF1 ( ortholog_one2one ) Macaque_ SUMF1 ( ortholog_one2one ) Mouse_ Sumf1 ( ortholog_one2one ) Pig_ SUMF1 ( ortholog_one2one ) Rat_ Sumf1 ( ortholog_one2one ) Rabbit_ SUMF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SUMF2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart. {ECO:0000269|PubMed:15962010}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1Y1E (X-ray 1.73A ) 1Y1F (X-ray 1.80A ) 1Y1G (X-ray 1.67A ) 1Y1H (X-ray 1.67A ) 1Y1I (X-ray 2.61A ) 1Y1J (X-ray 1.55A ) 1Z70 (X-ray 1.15A ) 2AFT (X-ray 1.66A ) 2AFY (X-ray 1.49A ) 2AII (X-ray 1.54A ) 2AIJ (X-ray 1.55A ) 2AIK (X-ray 1.73A ) 2HI8 (X-ray 1.64A ) 2HIB (X-ray 2.00A ) |
| DBSNP | rs200142963 rs2819590 rs137852850 rs757323641 rs137852854 rs759888604 rs1057517363 rs764215221 rs387906976 rs763243827 rs137852849 rs137852848 rs137852852 rs137852853 rs137852847 rs137852846 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000269|PubMed:15657036, ECO:0000269|PubMed:15962010, ECO:0000269|PubMed:18266766, ECO:0000269|PubMed:21224894}. |
| Mouse PG classification | NA |
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