| Gene Information | |
|---|---|
| Gene Name | SULF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 871 |
| Protein Names | Extracellular sulfatase Sulf-1 (hSulf-1) (EC 3.1.6.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000137573 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8IWU6 |
| Gene Card | SULF1 |
| Uniprot ID | Q8IWU6 |
| Pfam | PF12548; PF00884 |
| In ASD | no |
| Allosteric Prediction | no (-0.820077997) |
| Ortholog in Animals | Alpaca_ SULF1 ( ortholog_one2one ) Dog_ SULF1 ( ortholog_one2one ) GuineaPig_ SULF1 ( ortholog_one2one ) Macaque_ SULF1 ( ortholog_one2one ) Mouse_ Sulf1 ( ortholog_one2one ) Pig_ SULF1 ( ortholog_one2one ) Rat_ Sulf1 ( ortholog_one2one ) Rabbit_ SULF1 ( ortholog_one2one ) |
| Ohnologs | GNS, SULF2 |
| Paralogs | IDS, ARSA, ARSL, STS, ARSI, ARSG, ARSH, SGSH, GALNS, SULF2, GNS, ARSB, ARSJ, ARSF, ARSD, ARSK |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}. |
| Mouse PG classification | NA |
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