| Gene Information | |
|---|---|
| Gene Name | MIB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1006 |
| Protein Names | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000101752 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q86YT6 |
| Gene Card | MIB1 |
| Uniprot ID | Q86YT6 |
| Pfam | PF12796; PF13637; PF06701; PF18346; PF00569 |
| In ASD | no |
| Allosteric Prediction | no (-0.389353307) |
| Ortholog in Animals | Alpaca_ MIB1 ( ortholog_one2one ) Dog_ MIB1 ( ortholog_one2one ) GuineaPig_ MIB1 ( ortholog_one2one ) Macaque_ MIB1 ( ortholog_one2one ) Mouse_ Mib1 ( ortholog_one2one ) Pig_ MIB1 ( ortholog_one2one ) Rat_ Mib1 ( ortholog_one2one ) Rabbit_ MIB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MIB2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. {ECO:0000269|PubMed:10718198}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001293(Rat);0.022857(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4TSE (X-ray 2.06A ) 4XI6 (X-ray 2.04A ) 4XI7 (X-ray 2.05A ) 4XIB (X-ray 2.15A ) |
| DBSNP | rs755375969 rs200035428 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:24121310}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310}. Cell membrane {ECO:0000250}. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}. |
| Mouse PG classification | NA |
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