| Gene Information | |
|---|---|
| Gene Name | RBBP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 425 |
| Protein Names | Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000162521 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q09028 |
| Gene Card | RBBP4 |
| Uniprot ID | Q09028 |
| Pfam | PF12265; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.261623135) |
| Ortholog in Animals | Alpaca_ RBBP4 ( ortholog_one2one ) Dog_ RBBP4 ( ortholog_one2one ) GuineaPig_ RBBP4 ( ortholog_one2one ) Mouse_ Rbbp4 ( ortholog_one2one ) Rat_ RGD1563620 ( ortholog_one2many ) Rabbit_ RBBP4 ( ortholog_one2one ) |
| Ohnologs | RBBP7 |
| Paralogs | GRWD1, GEMIN5, WDR59, ERCC8, WDR77, RBBP7, WDR73, PEX7, WDR24 |
| Tissue | NA |
| Tissue Specificity | Expressed in neuroblastoma cells. {ECO:0000269|PubMed:30026490}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.113821(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XU7 (X-ray 1.90A ) 3GFC (X-ray 2.30A ) 4PBY (X-ray 2.50A ) 4PBZ (X-ray 2.15A ) 4PC0 (X-ray 2.50A ) 4R7A (X-ray 1.85A ) 5FXY (X-ray 3.20A ) 5VTB (X-ray 2.40A ) 5WAI (X-ray 2.90A ) 5WAK (X-ray 3.20A ) 5XWR (X-ray 2.69A ) 5XXQ (X-ray 1.90A ) 5Y1U (X-ray 2.14A ) 6BW3 (X-ray 2.20A ) 6BW4 (X-ray 2.00A ) 6C23 (EM 3.90A ) 6C24 (EM 3.50A ) 6G16 (X-ray 2.80A ) 6NQ3 (X-ray 2.89A ) 6WKR (EM 3.50A ) 6ZRC (X-ray 2.60A ) 6ZRD (X-ray 2.50A ) 7AOA (EM 19.40A ) 7KSO (EM 3.90A ) 7KSR (EM 4.10A ) 7KTP (EM 4.80A ) 7M40 (X-ray 1.88A ) 7N40 (X-ray 2.55A ) 7R1D (EM 3.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10220405, ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:8858152}. Chromosome, telomere {ECO:0000269|PubMed:30045876}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137}. |
| Mouse PG classification | NA |
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