| Gene Information | |
|---|---|
| Gene Name | CASP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 479 |
| Protein Names | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] |
| Target Name | caspase-8 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000064012 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14790 |
| Gene Card | CASP8 |
| Uniprot ID | Q14790 |
| Pfam | PF01335 |
| In ASD | yes |
| Allosteric Prediction | yes (1.109139354) |
| Ortholog in Animals | Alpaca_ CASP8 ( ortholog_one2one ) Dog_ CASP8 ( ortholog_one2one ) GuineaPig_ CASP8 ( ortholog_one2one ) Macaque_ CASP8 ( ortholog_one2one ) Mouse_ Casp8 ( ortholog_one2one ) Pig_ CASP8 ( ortholog_one2one ) Rat_ Casp8 ( ortholog_one2one ) |
| Ohnologs | CASP6 |
| Paralogs | PYCARD, CASP14, CASP2, CASP6, CFLAR, CASP10, CARD18, CASP9, CASP1, CARD16, CASP5, CASP4, CASP3, CASP7, PYDC1, CASP12 |
| Tissue | appendix, spleen |
| Tissue Specificity | Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.449977(Rat);0.065841(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1F9E (X-ray 2.90A ) 1I4E (X-ray 3.00A ) 1QDU (X-ray 2.80A ) 1QTN (X-ray 1.20A ) 2C2Z (X-ray 1.95A ) 2FUN (X-ray 3.00A ) 2K7Z (NMR - ) 2Y1L (X-ray 1.80A ) 3H11 (X-ray 1.90A ) 3KJN (X-ray 1.80A ) 3KJQ (X-ray 1.80A ) 4JJ7 (X-ray 1.18A ) 4PRZ (X-ray 2.12A ) 4PS1 (X-ray 1.73A ) 4ZBW (X-ray 2.20A ) 5H31 (X-ray 3.17A ) 5H33 (X-ray 3.60A ) 5JQE (X-ray 3.16A ) 5L08 (EM 4.60A ) 6AGW (X-ray 2.09A ) 6PX9 (X-ray 2.88A ) 7DEE (NMR - ) 7LVJ (X-ray 1.50A ) 7LVM (X-ray 1.47A ) |
| DBSNP | rs35976359 rs17860424 rs1045485 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9JHX4}. Nucleus {ECO:0000250|UniProtKB:Q9JHX4}. |
| Mouse PG classification | NA |
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