| Gene Information | |
|---|---|
| Gene Name | LIPE |
| Organism | Homo sapiens (Human) |
| Gene Length | 1076 |
| Protein Names | Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH) |
| Target Name | hormone sensitive lipase |
| Target Type | Successful target |
| Gene Age | 1064 ( ENSG00000079435 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q05469 |
| Gene Card | LIPE |
| Uniprot ID | Q05469 |
| Pfam | PF07859; PF06350 |
| In ASD | no |
| Allosteric Prediction | yes (0.444793544) |
| Ortholog in Animals | Alpaca_ LIPE ( ortholog_one2one ) Dog_ LIPE ( ortholog_one2one ) GuineaPig_ LIPE ( ortholog_one2one ) Macaque_ LIPE ( ortholog_one2one ) Mouse_ Lipe ( ortholog_one2one ) Pig_ LIPE ( ortholog_one2one ) Rat_ Lipe ( ortholog_one2one ) Rabbit_ LIPE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | adipose.tissue, testis |
| Tissue Specificity | Testis. {ECO:0000269|PubMed:8812477}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16975750 rs34080774 rs34348028 rs16975748 rs34996020 rs3745238 rs35938529 rs33921216 rs7246232 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17026959}. Membrane, caveola {ECO:0000269|PubMed:16803459, ECO:0000269|PubMed:17026959}. Cytoplasm, cytosol {ECO:0000269|PubMed:17026959}. Lipid droplet {ECO:0000250|UniProtKB:P54310}. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Phosphorylation by AMPK reduces its translocation towards the lipid droplets (By similarity). {ECO:0000250|UniProtKB:P54310, ECO:0000269|PubMed:17026959}. |
| Mouse PG classification | NA |
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