| Gene Information | |
|---|---|
| Gene Name | STOM |
| Organism | Homo sapiens (Human) |
| Gene Length | 288 |
| Protein Names | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000148175 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P27105 |
| Gene Card | STOM |
| Uniprot ID | P27105 |
| Pfam | PF01145 |
| In ASD | no |
| Allosteric Prediction | no (-0.06007329) |
| Ortholog in Animals | Alpaca_ STOM ( ortholog_one2one ) Dog_ STOM ( ortholog_one2one ) GuineaPig_ STOM ( ortholog_one2one ) Macaque_ STOM ( ortholog_one2one ) Mouse_ Stom ( ortholog_one2one ) Pig_ STOM ( ortholog_one2one ) Rat_ Stom ( ortholog_one2one ) Rabbit_ STOM ( ortholog_one2one ) |
| Ohnologs | STOML3 |
| Paralogs | STOML3, NPHS2, STOML1, STOML2 |
| Tissue | NA |
| Tissue Specificity | Detected in erythrocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:1547348, ECO:0000269|PubMed:23219802}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7WH3 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9243190}; Peripheral membrane protein {ECO:0000269|PubMed:9243190}; Cytoplasmic side {ECO:0000269|PubMed:9243190}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9243190}. Cell membrane {ECO:0000269|PubMed:12130500}; Lipid-anchor {ECO:0000269|PubMed:12130500}; Cytoplasmic side {ECO:0000269|PubMed:12130500}. Membrane raft {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:23219802}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P54116}. Note=Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190). Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190). Associates with alpha-granular lipid rafts (PubMed:12130500). Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:9243190}. |
| Mouse PG classification | NA |
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