Gene Information
Gene NameS1PR1
OrganismHomo sapiens (Human)
Gene Length382
Protein NamesSphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)
Target Namesphingosine-1-phosphate receptor 1
Target TypeSuccessful target
Gene Age645 ( ENSG00000170989 )
Evolutionary StageEumetazoa
AlphaFoldDBP21453
Gene CardS1PR1
Uniprot IDP21453
PfamPF00001
In ASDyes
Allosteric Predictionyes (1.114204046)
Ortholog in AnimalsAlpaca_ S1PR1 ( ortholog_one2one )
Dog_ S1PR1 ( ortholog_one2one )
GuineaPig_ S1PR1 ( ortholog_one2one )
Macaque_ S1PR1 ( ortholog_one2one )
Mouse_ S1pr1 ( ortholog_one2one )
Pig_ S1PR1 ( ortholog_one2one )
Rat_ S1pr1 ( ortholog_one2one )
Rabbit_ S1PR1 ( ortholog_one2one )
OhnologsLPAR2, S1PR4, S1PR5, GPR3, LPAR1, S1PR3
ParalogsGPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC1R, MC2R, MC3R, MC4R, LPAR1, LPAR2, LPAR3, S1PR5, S1PR2, S1PR3, S1PR4
TissueNA
Tissue SpecificityEndothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3V2W  (X-ray  3.35A  )  3V2Y  (X-ray  2.80A  )  7EO2  (EM  2.89A  )  7EO4  (EM  2.86A  )  7EVY  (EM  2.98A  )  7EVZ  (EM  3.07A  )  7EW0  (EM  3.42A  )  7EW7  (EM  3.27A  )  7TD3  (EM  3.00A  )  7TD4  (EM  2.60A  )  7WF7  (EM  3.40A  ) 
DBSNP rs4987250  rs11542632  rs7549921 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:29185452};
Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Mouse PG classificationNA
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