| Gene Information | |
|---|---|
| Gene Name | STMN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 149 |
| Protein Names | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) |
| Target Name | stmn1 messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000117632 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P16949 |
| Gene Card | STMN1 |
| Uniprot ID | P16949 |
| Pfam | PF00836 |
| In ASD | no |
| Allosteric Prediction | no (-0.241710273) |
| Ortholog in Animals | Alpaca_ STMN1 ( ortholog_one2one ) Dog_ STMN1 ( ortholog_one2one ) GuineaPig_ STMN1 ( ortholog_one2one ) Macaque_ STMN1 ( ortholog_one2one ) Mouse_ Stmn1 ( ortholog_one2one ) Pig_ STMN1 ( ortholog_one2one ) Rat_ AABR07030375.1 ( ortholog_one2one ) |
| Ohnologs | STMN2 |
| Paralogs | STMND1, STMN4, STMN3, STMN2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. {ECO:0000269|PubMed:12676564, ECO:0000269|PubMed:1917919}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. |
| Mouse PG classification | NA |
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