Gene Information
Gene NameSTK4
OrganismHomo sapiens (Human)
Gene Length487
Protein NamesSerine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Target Namemst-1 protein kinase
Target TypeLiterature-reported target
Gene Age424 ( ENSG00000101109 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ13043
Gene CardSTK4
Uniprot IDQ13043
PfamPF11629; PF00069
In ASDno
Allosteric Predictionyes (0.256015603)
Ortholog in AnimalsAlpaca_ STK4 ( ortholog_one2one )
Dog_ STK4 ( ortholog_one2one )
GuineaPig_ STK4 ( ortholog_one2one )
Macaque_ STK4 ( ortholog_one2one )
Mouse_ Stk4 ( ortholog_one2one )
Pig_ STK4 ( ortholog_one2one )
Rat_ Stk4 ( ortholog_one2one )
Rabbit_ STK4 ( ortholog_one2one )
OhnologsSTK3
ParalogsPAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4
TissueNA
Tissue SpecificityExpressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:17932490}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.101296(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2JO8  (NMR  -  )  3COM  (X-ray  2.20A  )  4NR2  (X-ray  2.00A  )  4OH8  (X-ray  2.28A  )  5TWG  (X-ray  2.30A  )  5TWH  (X-ray  2.50A  )  6YAT  (X-ray  2.58A  )  8A5J  (X-ray  2.12A  ) 
DBSNP rs55850759  rs35447878  rs17420378  rs35944046  rs33963346 
Subcellular location [CC]Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Mouse PG classificationLPG
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