| Gene Information | |
|---|---|
| Gene Name | SLC5A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 664 |
| Protein Names | Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1) |
| Target Name | sodium/glucose cotransporter 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000100170 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P13866 |
| Gene Card | SLC5A1 |
| Uniprot ID | P13866 |
| Pfam | PF00474 |
| In ASD | no |
| Allosteric Prediction | yes (1.061463844) |
| Ortholog in Animals | Alpaca_ SLC5A1 ( ortholog_one2one ) Dog_ SLC5A1 ( ortholog_one2one ) GuineaPig_ SLC5A1 ( ortholog_one2one ) Macaque_ SLC5A1 ( ortholog_one2one ) Mouse_ Slc5a1 ( ortholog_one2one ) Pig_ SLC5A1 ( ortholog_one2one ) Rat_ Slc5a1 ( ortholog_one2one ) Rabbit_ SLC5A1 ( ortholog_one2one ) |
| Ohnologs | SLC5A2, SLC5A11 |
| Paralogs | SLC5A11, SLC5A5, SLC5A8, SLC5A6, SLC5A9, SLC5A3, SLC5A10, SLC5A4, SLC5A2, SLC5A12, SLC5A7 |
| Tissue | small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Expressed in intestine (PubMed:2490366). Expressed in endometrial cells (PubMed:28974690). {ECO:0000269|PubMed:2490366, ECO:0000269|PubMed:28974690}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 7SL8 (EM 3.40A ) 7SLA (EM 3.15A ) |
| DBSNP | rs121912669 rs121912668 rs17683011 rs371505974 rs17683430 rs200406921 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:26945065}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | HPG |
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