| Gene Information | |
|---|---|
| Gene Name | STK11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 433 |
| Protein Names | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000118046 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15831 |
| Gene Card | STK11 |
| Uniprot ID | Q15831 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.071558189) |
| Ortholog in Animals | Alpaca_ STK11 ( ortholog_one2one ) Dog_ STK11 ( ortholog_one2one ) GuineaPig_ STK11 ( ortholog_one2one ) Macaque_ STK11 ( ortholog_one2one ) Mouse_ Stk11 ( ortholog_one2one ) Pig_ STK11 ( ortholog_one2one ) Rat_ Stk11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DCLK3, PHKG1, MYLK4, CAMKK1, CAMKK2, DCLK2, PSKH1, PNCK, CAMK1D, CAMKV, CAMK2B, CAMK1, STK33, PHKG2, DCLK1, PSKH2, CAMK2G, MYLK2, CAMK2D, CAMK2A, MYLK3, CAMK1G |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Strongest expression in testis and fetal liver. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.764209(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WTK (X-ray 2.65A ) 4ZDR (X-ray 2.90A ) 5WXN (X-ray 2.93A ) |
| DBSNP | rs137853080 rs1599915144 rs137853077 rs1057520039 rs1568690463 rs764449808 rs137853081 rs137853078 rs1599926499 rs730881979 rs1057520041 rs1568707668 rs121913315 rs121913316 rs121913315 rs121913317 rs730881981 rs1555738372 rs1057520038 rs1057520017 rs929783669 rs137853082 rs121913322 rs1568710381 rs1057520042 rs786202431 rs367807476 rs59912467 rs587782835 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. {ECO:0000250}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:23612973}. Cytoplasm {ECO:0000269|PubMed:23612973}. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment. |
| Mouse PG classification | NA |
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