| Gene Information | |
|---|---|
| Gene Name | TPM4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 248 |
| Protein Names | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) |
| Target Name | tropomyosin alpha-4 chain |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000167460 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P67936 |
| Gene Card | TPM4 |
| Uniprot ID | P67936 |
| Pfam | PF00261 |
| In ASD | no |
| Allosteric Prediction | no (-0.075204572) |
| Ortholog in Animals | Alpaca_ TPM4 ( ortholog_one2one ) GuineaPig_ TPM4 ( ortholog_one2one ) Mouse_ Tpm4 ( ortholog_one2one ) Pig_ TPM4 ( ortholog_one2one ) Rat_ Tpm4 ( ortholog_one2one ) Rabbit_ TPM4 ( ortholog_one2one ) |
| Ohnologs | TPM1, TPM3, TPM2 |
| Paralogs | TPM2, TPM3, TPM1 |
| Tissue | NA |
| Tissue Specificity | Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). {ECO:0000269|PubMed:1836432}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P09495}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P09495}. |
| Mouse PG classification | NA |
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