| Gene Information | |
|---|---|
| Gene Name | STIMATE |
| Organism | Homo sapiens (Human) |
| Gene Length | 294 |
| Protein Names | Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000213533 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86TL2 |
| Gene Card | STIMATE |
| Uniprot ID | Q86TL2 |
| Pfam | PF12400 |
| In ASD | no |
| Allosteric Prediction | no (-0.245987989) |
| Ortholog in Animals | Alpaca_ STIMATE ( ortholog_one2one ) Dog_ STIMATE ( ortholog_one2one ) GuineaPig_ STIMATE ( ortholog_one2one ) Macaque_ STIMATE ( ortholog_one2one ) Mouse_ Stimate ( ortholog_one2one ) Pig_ STIMATE ( ortholog_one2one ) Rat_ Stimate ( ortholog_one2one ) Rabbit_ STIMATE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MUSTN1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:26322679}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}; Multi-pass membrane protein {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable). {ECO:0000269|PubMed:26644574, ECO:0000305|PubMed:26322679}. |
| Mouse PG classification | NA |
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