| Gene Information | |
|---|---|
| Gene Name | STIM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 685 |
| Protein Names | Stromal interaction molecule 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000167323 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q13586 |
| Gene Card | STIM1 |
| Uniprot ID | Q13586 |
| Pfam | PF07647; PF16533 |
| In ASD | no |
| Allosteric Prediction | yes (0.257576674) |
| Ortholog in Animals | Alpaca_ STIM1 ( ortholog_one2one ) Dog_ STIM1 ( ortholog_one2one ) GuineaPig_ STIM1 ( ortholog_one2one ) Macaque_ STIM1 ( ortholog_one2one ) Mouse_ Stim1 ( ortholog_one2one ) Pig_ STIM1 ( ortholog_one2one ) Rat_ Stim1 ( ortholog_one2one ) Rabbit_ STIM1 ( ortholog_one2one ) |
| Ohnologs | STIM2 |
| Paralogs | STIM2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed in various human primary cells and tumor cell lines. {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:11463338}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2K60 (NMR - ) 2MAJ (NMR - ) 2MAK (NMR - ) 3TEQ (X-ray 1.90A ) 4O9B (X-ray 2.60A ) 6YEL (NMR - ) |
| DBSNP | rs397515436 rs748277951 rs397514675 rs397514676 rs397514677 rs527236030 rs483352867 rs1057519505 rs397514671 rs35960304 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:11004585, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:27185316, ECO:0000269|PubMed:28219928}. Endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:27185316}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184}. Sarcoplasmic reticulum {ECO:0000269|PubMed:25326555}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159). Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the cell membrane (PubMed:27185316). Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:27185316}. |
| Mouse PG classification | LPG |
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