| Gene Information | |
|---|---|
| Gene Name | MYZAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 466 |
| Protein Names | Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000263155 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P0CAP1 |
| Gene Card | MYZAP |
| Uniprot ID | P0CAP1 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.295405927) |
| Ortholog in Animals | GuineaPig_ MYZAP ( ortholog_one2one ) Macaque_ MYZAP ( ortholog_one2one ) Mouse_ Myzap ( ortholog_one2one ) Pig_ MYZAP ( ortholog_one2one ) Rat_ Myzap ( ortholog_one2one ) Rabbit_ MYZAP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TUFT1, CCDC68, POLR2M |
| Tissue | left.atrium, left.ventricle, pulmonary.valve |
| Tissue Specificity | Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. Expressed in arrector pili muscle (at protein level) (PubMed:29034528). {ECO:0000269|PubMed:15233991, ECO:0000269|PubMed:20093627, ECO:0000269|PubMed:29034528}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KXS (NMR - ) |
| DBSNP | rs16977629 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5EB94}. Cell membrane {ECO:0000250|UniProtKB:Q5EB94}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5EB94}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q5EB94}. Cell junction {ECO:0000269|PubMed:18849881, ECO:0000269|PubMed:21240187}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin. {ECO:0000250|UniProtKB:Q5EB94}. |
| Mouse PG classification | NA |
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