Gene Information
Gene NameSPTLC2
OrganismHomo sapiens (Human)
Gene Length562
Protein NamesSerine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)
Target Nameserine palmitoyltransferase 2
Target TypeNA
Gene Age680 ( ENSG00000100596 )
Evolutionary StageEuk+Bac
AlphaFoldDBO15270
Gene CardSPTLC2
Uniprot IDO15270
PfamPF00155
In ASDno
Allosteric Predictionyes (0.137919647)
Ortholog in AnimalsAlpaca_ SPTLC2 ( ortholog_one2one )
Dog_ SPTLC2 ( ortholog_one2one )
GuineaPig_ SPTLC2 ( ortholog_one2one )
Macaque_ SPTLC2 ( ortholog_one2one )
Mouse_ Sptlc2 ( ortholog_one2one )
Pig_ SPTLC2 ( ortholog_one2one )
Rat_ Sptlc2 ( ortholog_one2one )
Rabbit_ SPTLC2 ( ortholog_one2one )
OhnologsSPTLC3
ParalogsGCAT, ALAS2, SPTLC3, ALAS1, SPTLC1
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:17023427}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6M4N  (EM  3.80A  )  6M4O  (EM  3.40A  )  7CQI  (EM  3.20A  )  7CQK  (EM  3.30A  )  7K0I  (EM  3.30A  )  7K0J  (EM  3.10A  )  7K0K  (EM  2.60A  )  7K0L  (EM  3.40A  )  7K0M  (EM  2.90A  )  7K0N  (EM  3.10A  )  7K0O  (EM  3.10A  )  7K0P  (EM  3.10A  )  7K0Q  (EM  3.30A  ) 
DBSNP rs864621998  rs775437084  rs267607090  rs267607089  rs267607091 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P97363};
Single-pass membrane protein {ECO:0000250|UniProtKB:P97363}.
Mouse PG classificationLPG
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