| Gene Information | |
|---|---|
| Gene Name | MERTK |
| Organism | Homo sapiens (Human) |
| Gene Length | 999 |
| Protein Names | Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK) |
| Target Name | tyrosine-protein kinase mer |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000153208 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q12866 |
| Gene Card | MERTK |
| Uniprot ID | Q12866 |
| Pfam | PF00041; PF00047; PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (0.626883488) |
| Ortholog in Animals | Alpaca_ MERTK ( ortholog_one2one ) Dog_ MERTK ( ortholog_one2one ) GuineaPig_ MERTK ( ortholog_one2one ) Macaque_ MERTK ( ortholog_one2one ) Mouse_ Mertk ( ortholog_one2one ) Pig_ MERTK ( ortholog_one2one ) Rat_ Mertk ( ortholog_one2one ) Rabbit_ MERTK ( ortholog_one2one ) |
| Ohnologs | TYRO3, AXL |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DBJ (NMR - ) 2P0C (X-ray 2.40A ) 3BPR (X-ray 2.80A ) 3BRB (X-ray 1.90A ) 3TCP (X-ray 2.69A ) 4M3Q (X-ray 2.72A ) 4MH7 (X-ray 2.51A ) 4MHA (X-ray 2.59A ) 5K0K (X-ray 2.54A ) 5K0X (X-ray 2.23A ) 5TC0 (X-ray 2.24A ) 5TD2 (X-ray 2.68A ) 5U6C (X-ray 2.10A ) 6MEP (X-ray 2.89A ) 7AAX (X-ray 1.76A ) 7AAY (X-ray 1.87A ) 7AAZ (X-ray 1.85A ) 7AB0 (X-ray 1.74A ) 7AB1 (X-ray 1.93A ) 7AB2 (X-ray 1.78A ) 7AVX (X-ray 2.44A ) 7AVY (X-ray 2.31A ) 7AVZ (X-ray 2.04A ) 7AW0 (X-ray 1.89A ) 7AW1 (X-ray 1.98A ) 7AW2 (X-ray 2.10A ) 7AW3 (X-ray 1.99A ) 7AW4 (X-ray 1.98A ) 7CQE (X-ray 2.69A ) 7DXL (X-ray 3.15A ) 7M5Z (X-ray 3.06A ) 7OAM (X-ray 2.65A ) 7OLS (X-ray 1.89A ) 7OLV (X-ray 2.13A ) 7OLX (X-ray 1.98A ) |
| DBSNP | rs35898499 rs13027171 rs56205303 rs1475870132 rs7588635 rs766215580 rs34072093 rs34943572 rs34010621 rs7604639 rs35858762 rs2230515 rs113485015 rs56209758 rs55924349 rs2230516 rs2230517 rs377341255 rs201460398 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:32640697}; Single-pass type I membrane protein {ECO:0000250}. |
| Mouse PG classification | HPG |
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