| Gene Information | |
|---|---|
| Gene Name | STAT3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 770 |
| Protein Names | Signal transducer and activator of transcription 3 (Acute-phase response factor) |
| Target Name | signal transducer and activator of transcription 3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000168610 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P40763 |
| Gene Card | STAT3 |
| Uniprot ID | P40763 |
| Pfam | PF00017; PF01017; PF02864; PF02865 |
| In ASD | yes |
| Allosteric Prediction | yes (1.43014409) |
| Ortholog in Animals | Alpaca_ STAT3 ( ortholog_one2one ) Dog_ STAT3 ( ortholog_one2one ) GuineaPig_ STAT3 ( ortholog_one2one ) Macaque_ STAT3 ( ortholog_one2one ) Mouse_ Stat3 ( ortholog_one2one ) Pig_ STAT3 ( ortholog_one2one ) Rat_ Stat3 ( ortholog_one2one ) Rabbit_ STAT3 ( ortholog_one2one ) |
| Ohnologs | STAT1, STAT4, STAT6, STAT2 |
| Paralogs | STAT2, STAT4, STAT1, STAT5B, STAT5A, STAT6 |
| Tissue | NA |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195). {ECO:0000269|PubMed:31899195}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.035897(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5AX3 (X-ray 2.98A ) 5U5S (NMR - ) 6NJS (X-ray 2.70A ) 6NUQ (X-ray 3.15A ) 6QHD (X-ray 2.85A ) 6TLC (X-ray 2.90A ) |
| DBSNP | rs1803125 rs17878478 rs113994136 rs113994136 rs113994135 rs397514766 rs587777648 rs113994137 rs1064116 rs113994139 rs587777649 rs193922721 rs587777650 rs869312892 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:31899195}. Nucleus {ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:31899195}. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. |
| Mouse PG classification | NA |
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