| Gene Information | |
|---|---|
| Gene Name | GRHL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 626 |
| Protein Names | Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000158055 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8TE85 |
| Gene Card | GRHL3 |
| Uniprot ID | Q8TE85 |
| Pfam | PF04516 |
| In ASD | no |
| Allosteric Prediction | no (-0.725287547) |
| Ortholog in Animals | Alpaca_ GRHL3 ( ortholog_one2one ) Dog_ GRHL3 ( ortholog_one2one ) GuineaPig_ GRHL3 ( ortholog_one2one ) Macaque_ GRHL3 ( ortholog_one2one ) Mouse_ Grhl3 ( ortholog_one2one ) Pig_ GRHL3 ( ortholog_one2one ) Rat_ Grhl3 ( ortholog_one2one ) Rabbit_ GRHL3 ( ortholog_one2one ) |
| Ohnologs | GRHL2, GRHL1 |
| Paralogs | GRHL1, TFCP2L1, GRHL2, UBP1, TFCP2 |
| Tissue | esophagus, skin, esophagus.mucosa |
| Tissue Specificity | Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific. {ECO:0000269|PubMed:12549979}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2486668 rs34637004 rs752673677 rs879255245 rs946439477 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21081122}. |
| Mouse PG classification | NA |
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