| Gene Information | |
|---|---|
| Gene Name | USP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 963 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000114316 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13107 |
| Gene Card | USP4 |
| Uniprot ID | Q13107 |
| Pfam | PF06337; PF14836; PF00443 |
| In ASD | no |
| Allosteric Prediction | yes (0.132527111) |
| Ortholog in Animals | Alpaca_ USP4 ( ortholog_one2one ) Dog_ USP4 ( ortholog_one2one ) GuineaPig_ USP4 ( ortholog_one2one ) Macaque_ USP4 ( ortholog_one2one ) Mouse_ Usp4 ( ortholog_one2one ) Pig_ USP4 ( ortholog_one2one ) Rat_ Usp4 ( ortholog_one2one ) Rabbit_ USP4 ( ortholog_one2one ) |
| Ohnologs | USP11, USP15 |
| Paralogs | USP11, USP20, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons. {ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:7784062}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2Y6E (X-ray 2.40A ) 5CTR (X-ray 3.01A ) |
| DBSNP | rs9311440 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. |
| Mouse PG classification | NA |
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