| Gene Information | |
|---|---|
| Gene Name | STAG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1231 |
| Protein Names | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000101972 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N3U4 |
| Gene Card | STAG2 |
| Uniprot ID | Q8N3U4 |
| Pfam | PF08514 |
| In ASD | no |
| Allosteric Prediction | yes (0.14919881) |
| Ortholog in Animals | Alpaca_ STAG2 ( ortholog_one2one ) Dog_ STAG2 ( ortholog_one2one ) GuineaPig_ STAG2 ( ortholog_one2one ) Macaque_ STAG2 ( ortholog_one2one ) Mouse_ Stag2 ( ortholog_one2one ) Pig_ STAG2 ( ortholog_one2one ) Rat_ Stag2 ( ortholog_one2one ) Rabbit_ STAG2 ( ortholog_one2one ) |
| Ohnologs | STAG3, STAG1 |
| Paralogs | STAG1, STAG3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.117408(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4PJU (X-ray 3.05A ) 4PJW (X-ray 2.85A ) 4PK7 (X-ray 2.95A ) 6QNX (X-ray 2.70A ) |
| DBSNP | rs6655782 |
| Subcellular location [CC] | Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. |
| Mouse PG classification | NA |
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