| Gene Information | |
|---|---|
| Gene Name | ST7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 859 |
| Protein Names | Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000004866 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y561 |
| Gene Card | LRP12 |
| Uniprot ID | Q9Y561 |
| Pfam | PF00431; PF00057 |
| In ASD | no |
| Allosteric Prediction | no (-0.122160998) |
| Ortholog in Animals | Alpaca_ ST7 ( ortholog_one2one ) Dog_ ST7 ( ortholog_one2one ) GuineaPig_ ST7 ( ortholog_one2one ) Macaque_ ST7 ( ortholog_one2one ) Mouse_ St7 ( ortholog_one2one ) Pig_ ST7 ( ortholog_one2one ) Rat_ ST7 ( ortholog_one2one ) Rabbit_ ST7 ( ortholog_one2one ) |
| Ohnologs | ST7L |
| Paralogs | ST7L |
| Tissue | NA |
| Tissue Specificity | Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines. {ECO:0000269|PubMed:9927190}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16871494 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:12809483}; Single-pass type I membrane protein {ECO:0000269|PubMed:12809483}. Membrane, coated pit {ECO:0000269|PubMed:12809483}. |
| Mouse PG classification | NA |
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