| Gene Information | |
|---|---|
| Gene Name | ST3GAL5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (GM3 synthase) (Ganglioside GM3 synthase) (ST3Gal V) (ST3GalV) (Sialyltransferase 9) |
| Target Name | lactosylceramide alpha-2,3-sialyltransferase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000115525 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UNP4 |
| Gene Card | ST3GAL5 |
| Uniprot ID | Q9UNP4 |
| Pfam | PF00777 |
| In ASD | no |
| Allosteric Prediction | yes (0.059249169) |
| Ortholog in Animals | Alpaca_ ST3GAL5 ( ortholog_one2one ) Dog_ ST3GAL5 ( ortholog_one2one ) GuineaPig_ ST3GAL5 ( ortholog_one2one ) Macaque_ ST3GAL5 ( ortholog_one2one ) Mouse_ St3gal5 ( ortholog_one2one ) Pig_ ST3GAL5 ( ortholog_one2one ) Rat_ St3gal5 ( ortholog_one2one ) Rabbit_ ST3GAL5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ST6GALNAC5, C20orf173, ST3GAL4, ST3GAL3, ST3GAL2, ST6GAL1, ST6GALNAC4, ST6GALNAC3, ST6GALNAC6, ST6GALNAC2, ST3GAL6, ST6GAL2, ST6GALNAC1, ST3GAL1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis. mRNA widely distributed in human brain, but slightly elevated expression was observed in the cerebral cortex, temporal lobe, and putamen. {ECO:0000269|PubMed:9822625}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1138484 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
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