| Gene Information | |
|---|---|
| Gene Name | TPH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) |
| Target Name | tryptophan 5-hydroxylase 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000129167 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P17752 |
| Gene Card | TPH1 |
| Uniprot ID | P17752 |
| Pfam | PF00351 |
| In ASD | yes |
| Allosteric Prediction | yes (0.4605029) |
| Ortholog in Animals | Alpaca_ TPH1 ( ortholog_one2one ) Dog_ TPH1 ( ortholog_one2one ) GuineaPig_ TPH1 ( ortholog_one2one ) Macaque_ TPH1 ( ortholog_one2one ) Mouse_ Tph1 ( ortholog_one2one ) Pig_ TPH1 ( ortholog_one2one ) Rat_ Tph1 ( ortholog_one2one ) |
| Ohnologs | TPH2, PAH |
| Paralogs | TPH2, TH, PAH |
| Tissue | colon, duodenum, small.intestine, stomach, rectum |
| Tissue Specificity | [Isoform 2]: Seems to be less widely expressed than isoform 1. {ECO:0000269|PubMed:9751214}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MLW (X-ray 1.71A ) 3HF6 (X-ray 1.80A ) 3HF8 (X-ray 1.85A ) 3HFB (X-ray 1.92A ) 5J6D (X-ray 1.90A ) 5L01 (X-ray 1.90A ) 5TPG (X-ray 1.50A ) 7ZIF (X-ray 1.87A ) 7ZIG (X-ray 1.81A ) 7ZIH (X-ray 1.47A ) 7ZII (X-ray 1.63A ) 7ZIJ (X-ray 1.95A ) 7ZIK (X-ray 2.59A ) |
| DBSNP | NA |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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