Gene Information
Gene NameKIAA0871
OrganismHomo sapiens (Human)
Gene Length469
Protein NamesProtein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ7L099
Gene CardRUFY3
Uniprot IDQ7L099
PfamPF02759
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityOverexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321). {ECO:0000269|PubMed:25766321}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:25766321}. Endomembrane system {ECO:0000269|PubMed:20376209}. Cell projection, invadopodium {ECO:0000269|PubMed:25766321}. Perikaryon {ECO:0000250|UniProtKB:Q9D394}. Cell projection {ECO:0000250|UniProtKB:Q9D394}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D394}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9D394}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9D394}. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalized with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalized with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalized with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:20376209, ECO:0000269|PubMed:25766321}.
Mouse PG classificationNA
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