Gene Information
Gene NameSETD3
OrganismHomo sapiens (Human)
Gene Length594
Protein NamesActin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3)
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000183576 )
Evolutionary StageEukaryota
AlphaFoldDBQ86TU7
Gene CardSETD3
Uniprot IDQ86TU7
PfamPF09273; PF00856
In ASDno
Allosteric Predictionno (-1.084642005)
Ortholog in AnimalsAlpaca_ SETD3 ( ortholog_one2one )
Dog_ SETD3 ( ortholog_one2one )
GuineaPig_ SETD3 ( ortholog_one2one )
Macaque_ SETD3 ( ortholog_one2one )
Mouse_ Setd3 ( ortholog_one2one )
Pig_ SETD3 ( ortholog_one2one )
Rat_ Setd3 ( ortholog_one2one )
Rabbit_ SETD3 ( ortholog_one2one )
OhnologsNA
ParalogsSETD6, SETD4
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.065385(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3SMT  (X-ray  2.04A  6ICT  (X-ray  1.95A  6ICV  (X-ray  2.15A  6JAT  (X-ray  2.71A  6MBJ  (X-ray  1.78A  6MBK  (X-ray  1.69A  6MBL  (X-ray  2.20A  6OX0  (X-ray  1.75A  6OX1  (X-ray  1.95A  6OX2  (X-ray  2.09A  6OX3  (X-ray  1.78A  6OX4  (X-ray  2.29A  6OX5  (X-ray  2.10A  6V62  (X-ray  2.36A  6V63  (X-ray  2.02A  6WK1  (X-ray  1.89A  6WK2  (X-ray  1.76A  7LMS  (EM  3.50A 
DBSNP rs1740231 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:28442573, ECO:0000269|PubMed:30626964}. Nucleus {ECO:0000269|PubMed:28442573}. Note=Localizes mainly in the cytoplasm. {ECO:0000269|PubMed:28442573}.
Mouse PG classificationNA
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