| Gene Information | |
|---|---|
| Gene Name | ZW10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 779 |
| Protein Names | Centromere/kinetochore protein zw10 homolog |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 25 ( ENSG00000086827 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43264 |
| Gene Card | ZW10 |
| Uniprot ID | O43264 |
| Pfam | PF06248 |
| In ASD | no |
| Allosteric Prediction | yes (0.045593212) |
| Ortholog in Animals | Alpaca_ ZW10 ( ortholog_one2one ) Dog_ ZW10 ( ortholog_one2one ) GuineaPig_ ZW10 ( ortholog_one2one ) Macaque_ ZW10 ( ortholog_one2one ) Mouse_ Zw10 ( ortholog_one2one ) Pig_ ZW10 ( ortholog_one2one ) Rat_ Zw10 ( ortholog_one2one ) Rabbit_ ZW10 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.048889(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7QPG (EM 3.90A ) |
| DBSNP | rs2271796 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15029241}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15029241}; Peripheral membrane protein {ECO:0000269|PubMed:15029241}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11590237}. Lipid droplet {ECO:0000269|PubMed:30970241}. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241}. |
| Mouse PG classification | NA |
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