Gene Information
Gene NameSRSF2
OrganismHomo sapiens (Human)
Gene Length221
Protein NamesSerine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000161547 )
Evolutionary StageEukaryota
AlphaFoldDBQ01130
Gene CardSRSF2
Uniprot IDQ01130
PfamPF00076
In ASDno
Allosteric Predictionno (-0.779360742)
Ortholog in AnimalsAlpaca_ SRSF2 ( ortholog_one2one )
Dog_ SRSF2 ( ortholog_one2one )
Macaque_ SRSF2 ( ortholog_one2one )
Mouse_ Srsf2 ( ortholog_one2one )
Pig_ SRSF2 ( ortholog_one2one )
Rat_ Srsf2 ( ortholog_one2one )
OhnologsNA
ParalogsSRSF8, SRSF12, SRSF10
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2KN4  (NMR  2LEA  (NMR  2LEB  (NMR  2LEC  (NMR 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm.
Mouse PG classificationNA
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