| Gene Information | |
|---|---|
| Gene Name | SRY |
| Organism | Homo sapiens (Human) |
| Gene Length | 204 |
| Protein Names | Sex-determining region Y protein (Testis-determining factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 8 ( ENSG00000184895 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q05066 |
| Gene Card | SRY |
| Uniprot ID | Q05066 |
| Pfam | PF00505 |
| In ASD | no |
| Allosteric Prediction | no (-0.815192239) |
| Ortholog in Animals | Alpaca_ SRY ( ortholog_one2one ) Dog_ SRY ( ortholog_one2one ) Macaque_ SRY ( ortholog_one2one ) Mouse_ Sry ( ortholog_one2one ) Pig_ SRY ( ortholog_one2many ) Rat_ Sry3 ( ortholog_one2many ) Rat_ Sry ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | SOX12, SOX17, SOX13, SOX30, CFAP65, SOX21, SOX8, SOX7, SOX5, SOX14, SOX6, SOX9, SOX10, SOX1, SOX4, SOX18, SOX11, SOX3, SOX2, SOX15 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HRY (NMR - ) 1HRZ (NMR - ) 1J46 (NMR - ) 1J47 (NMR - ) 2GZK (NMR - ) 6EDB (X-ray 3.21A ) |
| DBSNP | rs104894971 rs764249635 rs104894957 rs104894969 rs104894968 rs104894959 rs104894972 rs104894974 rs104894964 rs104894956 rs104894966 rs104894973 rs104894973 rs104894976 |
| Subcellular location [CC] | Nucleus speckle {ECO:0000269|PubMed:11818535}. Cytoplasm {ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:19349578}. Nucleus {ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192, ECO:0000269|PubMed:16762365, ECO:0000269|PubMed:19349578, ECO:0000269|PubMed:28030592}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (PubMed:15297880). Colocalizes with SOX6 in speckles (PubMed:11818535). Colocalizes with CAML in the nucleus (PubMed:15746192). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (PubMed:19349578). {ECO:0000250|UniProtKB:Q05738, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192, ECO:0000269|PubMed:19349578}. |
| Mouse PG classification | NA |
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