| Gene Information | |
|---|---|
| Gene Name | CXCR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182) |
| Target Name | c-x-c chemokine receptor type 2 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000180871 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P25025 |
| Gene Card | CXCR2 |
| Uniprot ID | P25025 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999852906) |
| Ortholog in Animals | Alpaca_ CXCR2 ( ortholog_one2one ) Dog_ CXCR2 ( ortholog_many2many ) GuineaPig_ Cxcr2 ( ortholog_one2one ) Macaque_ CXCR2 ( ortholog_one2one ) Mouse_ Cxcr2 ( ortholog_one2one ) Rat_ Cxcr2 ( ortholog_one2one ) Rabbit_ CXCR1 ( ortholog_one2many ) |
| Ohnologs | CCR2, ACKR2, LPAR4, CCR4, CCR10, CXCR3 |
| Paralogs | GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR1, CXCR5, CXCR3, CXCR4 |
| Tissue | appendix, lung, spleen, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4Q3H (X-ray 1.44A ) 5TYT (X-ray 2.40A ) 6KVA (X-ray 2.20A ) 6KVF (X-ray 2.79A ) 6LFM (EM 3.50A ) 6LFO (EM 3.40A ) |
| DBSNP | rs138773569 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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