| Gene Information | |
|---|---|
| Gene Name | AMN |
| Organism | Homo sapiens (Human) |
| Gene Length | 453 |
| Protein Names | Protein amnionless [Cleaved into: Soluble protein amnionless] |
| Target Name | protein amnionless |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000166126 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BXJ7 |
| Gene Card | AMN |
| Uniprot ID | Q9BXJ7 |
| Pfam | PF14828 |
| In ASD | no |
| Allosteric Prediction | no (-0.241025807) |
| Ortholog in Animals | Alpaca_ AMN ( ortholog_one2one ) Dog_ AMN ( ortholog_one2one ) GuineaPig_ AMN ( ortholog_one2one ) Macaque_ AMN ( ortholog_one2one ) Mouse_ Amn ( ortholog_one2one ) Pig_ AMN ( ortholog_one2one ) Rat_ Amn ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | duodenum, kidney, small.intestine, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | Detected in proximal tubules in the kidney cortex (at protein level) (PubMed:14576052, PubMed:29402915). Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12590260, ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6GJE (X-ray 2.30A ) |
| DBSNP | rs119478058 rs375774640 rs386834176 |
| Subcellular location [CC] | [Isoform 1]: Apical cell membrane {ECO:0000269|PubMed:14576052}; Single-pass type I membrane protein {ECO:0000305|PubMed:30523278}. Cell membrane {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305|PubMed:14576052}. Membrane, coated pit {ECO:0000305|PubMed:14576052}.; [Soluble protein amnionless]: Secreted {ECO:0000269|PubMed:14576052}. |
| Mouse PG classification | LPG |
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