Gene Information
Gene NameSORBS3
OrganismHomo sapiens (Human)
Gene Length671
Protein NamesVinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Target NameNA
Target TypeNA
Gene Age1292 ( ENSG00000120896 )
Evolutionary StageMammalia
AlphaFoldDBO60504
Gene CardSORBS3
Uniprot IDO60504
PfamPF00018; PF14604; PF02208
In ASDno
Allosteric Predictionno (-0.715227308)
Ortholog in AnimalsAlpaca_ SORBS3 ( ortholog_one2one )
Dog_ SORBS3 ( ortholog_one2one )
GuineaPig_ SORBS3 ( ortholog_one2one )
Macaque_ SORBS3 ( ortholog_one2one )
Mouse_ Sorbs3 ( ortholog_one2one )
Pig_ SORBS3 ( ortholog_one2one )
Rat_ Sorbs3 ( ortholog_one2one )
Rabbit_ SORBS3 ( ortholog_one2one )
OhnologsSH3D19
ParalogsSH3GL3, SORBS1, SORBS2, SH3GLB1, SH3GLB2, NCF4, SH3RF3, SH3RF2, SH3GL1, SH3RF1, SH3D19, SH3GL2
TissueNA
Tissue SpecificityBoth isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2CT3  (NMR  -  )  2DLM  (NMR  -  )  2NWM  (NMR  -  )  2YUP  (NMR  -  ) 
DBSNP rs3758036  rs2449331  rs1047030 
Subcellular location [CC][Isoform Alpha]: Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.;
[Isoform Beta]: Cell junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.
Mouse PG classificationNA
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